TCO-PEG4-NHS ester

TCO-PEG4-NHS ester

TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition . Please contact us for GMP-grade inquiries. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.

Molecular structure of the compound BP-22418
    • Unit
    • Price
    • Qty
    • 25 MG
    • $287.00
    • 50 MG
    • $480.00
    • 100 MG
    • $704.00
    • 250 MG
    • $1242.00

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Product Citations

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    https://pubs.acs.org/doi/abs/10.1021/acsapm.3c01849
  2. Bohrmann, Lennart, Tobias Burghardt, Cristina Rodríguez-Rodríguez, Matthias M. Herth, Katayoun Saatchi, and Urs O. Häfeli Quantitative Evaluation of a Multimodal Aptamer-Targeted Long-Circulating Polymer for Tumor Targeting.. ACS Omega. 2022
    https://pubs.acs.org/doi/pdf/10.1021/acsomega.2c07761
  3. Cochran, M., Arias, D., Burke, R., Chu, D., Erdogan, G., Hood, M., ... & Doppalapudi, V. R. (2024). Structure–Activity Relationship of Antibody–Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody–siRNA Conjugates for Drug Development. Journal of medicinal chemistry.
    https://doi.org/10.1021/acs.jmedchem.4c00802
  4. G·施滕格尔, 余华, A·普赖斯, J·桑托斯, 皇甫钰奾, B·珀斯. RNA and DNA analysis using engineered surfaces. (CN118660973A)
    https://patents.google.com/patent/CN118660973A/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=27
  5. Gudrun Stengel, Byron Purse, Yu-Hsien Hwang-Fu, Jerome Santos. Multiplexed profiling of rna and dna modifications. (US20240110222A1)
    https://patents.google.com/patent/US20240110222A1/en?q=(BROADPHARM)&oq=BROADPHARM&sort=new&page=19
  6. Gudrun Stengel, Hua Yu, Andrew Price, Jerome Santos, Yu-Hsien, Hwang-Fu, Byron Purse. Rna and dna analysis using engineered surfaces. (US20250263794A1)
    https://patents.google.com/patent/US20250263794A1/en?q=(broadpharm)&num=100&oq=broadpharm&sort=new
  7. Modhiran, N., Lauer, S. M., Amarilla, A. A., Hewins, P., van den Broek, S. I. L., Low, Y. S., ... & Watterson, D. (2023). A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants. Iscience, 26(7), 107085.
    https://www.sciencedirect.com/science/article/pii/S2589004223011628
  8. Modhiran, Naphak, Simon Malte Lauer, Alberto A. Amarilla, Peter Hewins, Sara Irene Lopes van den Broek, Yu Shang Low, Nazia Thakur A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants. Iscience . 2023
    https://www.sciencedirect.com/science/article/pii/S2589004223011628
  9. Momin, N., Pabel, S., Rudra, A., Kumowski, N., Lee, I. H., Mentkowski, K., ... & Hulsmans, M. (2024). Therapeutic Spp1 silencing in TREM2+ cardiac macrophages suppresses atrial fibrillation. bioRxiv.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326243/
  10. Whitney S, Craig B, et al. Ferritin as a Natural Protein Scaffold: Building a Multivalent Ferritin-Fab Conjugate. Chromatography Online. 2019. 37(11). pp. 30-35.
    http://www.chromatographyonline.com/ferritin-natural-protein-scaffold-building-multivalent-ferritin-fab-conjugate?pageID=1