TCO-NHS ester

TCO-NHS ester

TCO-NHS Ester is an popular reagent to label amine-containing compound or biomolecule, TCOI enable fast click chemistry with tetrazine. Please contact us for GMP-grade inquiries. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.

Molecular structure of the compound BP-22417
    • Unit
    • Price
    • Qty
    • 25 MG
    • $150.00
    • 100 MG
    • $525.00
    • 250 MG
    • $890.00
    • 500 MG
    • $1550.00

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Product Citations

  1. Gao, H., Pol, M., Makara, C. A., Song, J., Zhang, H., Zou, X., ... & Jia, X. (2025). Bio-orthogonal tuning of matrix properties during 3D cell culture to induce morphological and phenotypic changes. Nature Protocols, 20(3), 727-778.
    https://www.nature.com/articles/s41596-024-01066-z
  2. Hu, H., & Zhang, C. (2025). Conjugation of Multiple Proteins Onto the Surface of PLGA/Lipid Hybrid Nanoparticles. Journal of Biomedical Materials Research Part A, 113(1), e37807.
    https://doi.org/10.1002/jbm.a.37807
  3. Kellner, A. V., Hunter, R., Do, P., Eggert, J., Jaffe, M., Geitgey, D. K., ... & Salaita, K. (2024). The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces. bioRxiv, 2024-01.
    https://scholar.googleusercontent.com/scholar?q=cache:_MzjtxrMe88J:scholar.google.com/&hl=en&as_sdt=0,36
  4. Rashid, Sk Aysha, Yixiao Dong, Hiroaki Ogasawara, Maia Vierengel, Mark Edoho Essien, and Khalid Salaita. All-Covalent Nuclease-Resistant and Hydrogel-Tethered DNA Hairpin Probes Map pN Cell Traction Forces. ACS Applied Materials & Interfaces. 2023
    https://pubs.acs.org/doi/full/10.1021/acsami.3c04826