Sugar PEG

Sugar PEG


GalNAc, or N-acetylgalactosamine, is an amino sugar derivative of galactose that can recognize and bind to a cell surface protein, the asialoglycoprotein receptor (ASGPR), which is abundantly expressed on liver cells (hepatocytes). The binding affinity to the receptor increases exponentially if several GalNAc units are combined into a multivalent ligand. The affinity of the ASGPR for a trimer of GalNAc is 1,000-fold higher than a dimer or monomer. GalNAc technology has largely as an alternative of LNP delivery for liver disease targets. The GalNAc-conjugated siRNAs are used to treat a variety of diseases, including cancer, viral outbreaks, and Parkinson's Disease. Three GalNA-siRNA conjugates, namely, Lumasiran (2020), Inclisiran (2021), and Vutrisiran (2022), have been approved by FDA and introduced to the market.

In BroadPharm, we provide different active groups (Maleimide, Thiol, NHS, Amine, Azido, DBCO, Alkyl, TCO, Tetrazine, etc.) functionalized trivalent GalNac for versatile bioconjugations. We also offer GalNac-Lipid as upgraded LNP composites for hepatic specific LNP delivery systems. Our trivalent GalNAc, meaning that three GalNAc molecules are clustered and conjugated to one cargo molecule. This setup guarantees high affinity of the interaction between ASGPR and the GalNAc ligand, thus promoting optimal efficiency of cargo delivery to the liver.

Catalog Product Name Structure M.W. Purity Pricing
Azido-PEG-sugar
BP-22505Azido-PEG4-beta-D-glucoseMolecular structure of the compound: Azido-PEG4-beta-D-glucose381.498%Pricing
BP-23832Azido-PEG4-alpha-D-mannoseMolecular structure of the compound: Azido-PEG4-alpha-D-mannose381.498%Pricing
BP-403106-Azide-Trehalose (6-TreAz)Molecular structure of the compound: 6-Azide-Trehalose (6-TreAz)367.3Pricing
BP-23431N-azidoacetylglucosamine-tetraacylated (Ac4GlcNAz)Molecular structure of the compound: N-azidoacetylglucosamine-tetraacylated (Ac4GlcNAz)430.490%Pricing
BP-24306N-N-azidoacetylgalactosamine-tetraacylated (Ac4GalNAz)Molecular structure of the compound: N-N-azidoacetylgalactosamine-tetraacylated (Ac4GalNAz)430.495%Pricing
BP-40284KDO AzideMolecular structure of the compound: KDO Azide280.2Pricing
BP-417999AzNue5AcMolecular structure of the compound: 9AzNue5Ac334.3Pricing
BP-24243LG-PEG10-azideMolecular structure of the compound: LG-PEG10-azide866.9Pricing
BP-24244LG-PEG10-click-DBCO-OleicMolecular structure of the compound: LG-PEG10-click-DBCO-Oleic1407.7Pricing
Propargyl-PEG-sugar
BP-22508Propargyl-PEG5-beta-D-glucoseMolecular structure of the compound: Propargyl-PEG5-beta-D-glucose394.498%Pricing
BP-22596Propargyl-PEG5-beta-D-galactoseMolecular structure of the compound: Propargyl-PEG5-beta-D-galactose394.498%Pricing
BP-22510Propargyl-PEG5-tetra-Ac-beta-D-galactoseMolecular structure of the compound: Propargyl-PEG5-tetra-Ac-beta-D-galactose562.698%Pricing
BP-24305N-(4-pentynoyl)-glucosamine-tetraacylated (Ac4GlcAl)Molecular structure of the compound: N-(4-pentynoyl)-glucosamine-tetraacylated (Ac4GlcAl)427.4Pricing
BP-42044Ac4ManNAl (N-(4-pentynoyl)-mannosamine-tetraacylated)Molecular structure of the compound: Ac4ManNAl (N-(4-pentynoyl)-mannosamine-tetraacylated)427.495%Pricing
BP-40311O-Alkyne-Trehalose (O-AlkTMM)Molecular structure of the compound: O-Alkyne-Trehalose (O-AlkTMM)464.5Pricing
Trivalent GalNAc linker
BP-41316Tri-GalNAc(OAc)3 TFAMolecular structure of the compound: Tri-GalNAc(OAc)3 TFA1793.9Pricing
BP-41314Tri-GalNAc(OAc)3 CbzMolecular structure of the compound: Tri-GalNAc(OAc)3 Cbz1928.1Pricing
BP-41315Tri-GalNAc -COOHMolecular structure of the compound: Tri-GalNAc -COOH1736Pricing
BP-41312GalNAcMolecular structure of the compound: GalNAc2407.7Pricing
BP-41313GalnAc-L96 TEAMolecular structure of the compound: GalnAc-L96 TEA2507.8Pricing
Sugar bromide
BP-223592,3,4,6-tetra-o-acetyl-alpha-galactosylpyranosyl bromideMolecular structure of the compound: 2,3,4,6-tetra-o-acetyl-alpha-galactosylpyranosyl bromide411.296%Pricing
BP-225182,3,4,6-tetra-o-acetyl-alpha-D-glucosylpyranosyl bromideMolecular structure of the compound: 2,3,4,6-tetra-o-acetyl-alpha-D-glucosylpyranosyl bromide411.296%Pricing
Isopropylthio-sugar
BP-225031-(isopropylthio)-2,3,4,6-tetra-o-Ac-beta-D-GlucosylpyranoseMolecular structure of the compound: 1-(isopropylthio)-2,3,4,6-tetra-o-Ac-beta-D-Glucosylpyranose406.598%Pricing
Metaboling Labeling reagents
BP-543025-Ethynyl-2'-deoxyuridine (EdU)Molecular structure of the compound: 5-Ethynyl-2-deoxyuridine (EdU)252.2Pricing
BP-243035-Ethynyl Uridine (EU)Molecular structure of the compound: 5-Ethynyl Uridine (EU)268.2Pricing