Tri-GalNAc-PEG4-Mal is a functionalized ASGPR ligand with a PEG linker and maleimide group for cysteine conjugation. It enables efficient hepatocyte-specific delivery of RNA or Cas9 complexes via ASGPR-mediated endocytosis, supporting LYTAC research and targeted therapeutic development. The PEG linker imparts water solubility.
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