Target-Specific Linkers

Target-Specific Linkers

Target-Specific Linkers (TSLs) are a class of chemical linkers widely used in pharmaceutical research and development. These specialized molecules are designed to facilitate the precise and efficient delivery of therapeutic agents to specific cells or tissues, while minimizing off-target effects.

A typical TSL consists of two key components:

1. Targeting moiety - a functional group that selectively binds to a specific receptor or biomolecular target, such as an antibody, peptide, or ligand.
2. Chemically reactive linker - a functional group that enables attachment of a therapeutic payload, such as a small-molecule drug, siRNA, or other bioactive compound.

TSLs are engineered to selectively and covalently interact with target receptors, enabling targeted drug delivery that enhances therapeutic specificity and reduces systemic side effects.

TSLs are particularly valuable in oncology, where they enable the selective delivery of chemotherapy drugs to cancer cells, sparing healthy tissue. This targeted strategy improves treatment efficacy and reduces toxicity, ultimately leading to better patient outcomes.

BroadPharm offers a wide range of Target-Specific Linkers, including:

• Biotin linkers
• Sugar linkers
• PROTAC linkers
• Folic acid linkers
• Cysteine-specific linkers

These linkers are optimized for various applications in targeted drug delivery, bioconjugation, and molecular design.