Cantuzumab mertansine (SB-408075; huC242-DM1), is an anti-MUC1 sialylated carbohydrate, tumour-associated (CA242, cancer antigen 242), humanized monoclonal antibody conjugated to maytansinoid DM1 ([N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)-maytansine]) via a reductible SPP linker [N-succinimidyl 4-(2-pyridyldithio)pentanoate]. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts. Its molecular weight is 145kDa. This product is for research use only.
Product Details |
Species Reactivity | Human |
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Type | Antibody-drug conjugate |
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ADC antibody | Cantuzumab (anti-huC242) |
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ADC cytotoxin (drug) | DM1 |
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Immunogen | Human CanAg |
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DAR (Drug to Antibody Ratio) | N/A |
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Purity | 99% |
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Molecular Weight | 145kDa |
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Storage Condition | Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
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Storage Buffer | 1xPBS |