Trastuzumab-MMAE

Trastuzumab-MMAE is an antibody-drug conjugate (ADC) of Anti-Her2 human monoclonal antibody Trastuzumab with MMAE (Monomethyl auristatin E) through a cathepsin cleavable peptide linker (MC-VC-PAB-). MMAE is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent. The DAR of Trastuzumab-MMAE is n = 3.5 - 4.0. This product is used for research only. It can be used as a reference compound.

Product Details
Species Reactivity	Human
Host/Isotype	Cell culture/ IgG1
Class	Monoclonal
Type	Antibody-drug conjugate
Immunogen	Human Her2
DAR (Drug to Antibody Ratio)	3.5 - 4.0
Clone	Trastuzumab biosimilar
Conjugate	Trastuzumab conjugated with MC-VC-PAB-MMAE
Purity	>98%
Molecular Weight	~148kDa
Protein Concentration	1 mg/ml
Formulation	Liquid
Storage Condition	4°C for short time, -20°C or -80°C for long time.
Storage Buffer	50 mM Sodium Phosphate, 0.05% Tween-20, pH7.4