Trastuzumab-SN38

Trastuzumab-SN38 is an antibody-drug conjugate (ADC) of Anti-Her2 human monoclonal antibody Trastuzumab with SN38 through a cleavable linker. SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. The DAR of Trastuzumab-SN38 is 7 - 8. This product is used for research only. It can be used as a reference compound.

Product Details
Species Reactivity	Human
Host/Isotype	Cell culture/ IgG1
Class	Monoclonal
Type	Antibody-drug conjugate
Immunogen	Human Her2
DAR (Drug to Antibody Ratio)	7.0 - 8.0
Clone	Trastuzumab biosimilar
Conjugate	Trastuzumab conjugated with CL2A-SN38
Purity	>98%
Molecular Weight	~148kDa
Protein Concentration	1 mg/ml
Formulation	Liquid
Storage Condition	4°C for short time, -20°C or -80°C for long time.
Storage Buffer	50 mM Sodium Phosphate, 0.05% Tween-20, pH7.4