Sofituzumab Vedotin (DMUC5754A, RG-7458) is an antibody-drug conjugate (ADC) that contains the humanized IgG1 anti-MUC16 monoclonal antibody (mAb) and a potent anti-mitotic agent, monomethyl auristatin E (MMAE), linked through a protease-labile linker. DMUC5754A binds to the MUC16 extracellular domain with high affinity. Sofituzumab Vedotin has a Drug-to-antibody ratio (DAR) of 4.3, it's molecular weight is 155kDa. This product is for research use only.
Product Details |
Species Reactivity | Human |
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Type | Antibody-drug conjugate |
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ADC antibody | Sofituzumab (anti-MUC16) |
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ADC cytotoxin (drug) | MMAE |
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Immunogen | Human CA125 / MUC16 |
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DAR (Drug to Antibody Ratio) | ~ 4.3 |
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Purity | 98% |
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Molecular Weight | 155 kDa |
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Storage Condition | Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
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Storage Buffer | 1xPBS |