Brentuximab vedotin (ADCETRIS) is a CD30-directed antibody-drug conjugate (ADC) consisting of three components: 1) the chimeric IgG1 antibody cAC10, specific for human CD30, 2) the microtubule disrupting agent MMAE, and 3) a protease-cleavable linker that covalently attaches MMAE to cAC10. Brentuximab vedotin has an approximate molecular weight of 153 kDa. Approximately 4 molecules of MMAE are attached to each antibody molecule.This product is for research use only.
Product Details |
Species Reactivity | Human |
---|
Type | Antibody-drug conjugate |
---|
ADC antibody | Brentuximab (Anti-CD30) |
---|
ADC cytotoxin (drug) | MMAE |
---|
Immunogen | Human CD30 |
---|
DAR (Drug to Antibody Ratio) | ~4.2 |
---|
Purity | 99% |
---|
Molecular Weight | 153kDa |
---|
Storage Condition | Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
---|
Storage Buffer | 1x PBS |