Protein G-MMAF

Protein G-MMAF is a Protein-drug conjugate (PDC) of Protein G with MMAF (Monomethylauristatin F) through a linker. >95% protein G were conjugated with MMAF, the DPR (drug protein ratio) n = 1-3 drugs per protein. Protein G is expressed in group C and G streptococcal bacteria. It is a ~60-kDa cell surface protein. It binds to most mammalian immunoglobulins primarily through their Fc regions. MMAF is a synthetic antineoplastic agent and a potent inhibitor of tubulin polymerization which applied as a cytotoxic component of the anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. This product is for research use only.

Product Details
Species Reactivity	Bind to most mammalian immunoglobulins primarily through their Fc regions.
Source	E. coli
Type	Recombinant Protein
Measurement	A280 of 0.1% solution: 1.0
Isoelectric point (pI)	4.5
DAR (Drug to Antibody Ratio)	>95% protein conjugated, 1-3 drugs per protein
Conjugate	protein G conjugated with -MMAF
Purity	>95%
Molecular Weight	~21,600 (Apparent MW by SDS-PAGE: 32,000)
Protein Concentration	1 mg/ml
Formulation	Liquid
Storage Condition	4°C for short time, -20°C or -80°C for long time.
Storage Buffer	20 mM Sodium Borate, 6% Trehalose, pH8.0