Protein G-DXD (cleavable)

Protein G-DXD is a Protein-drug conjugate (PDC) of Protein G with topoisomerase inhibitor (DXD) conjugate through a cleavable linker. >95% protein G were conjugated with DXD, the DPR (drug protein ratio) n = 1-3 drugs per protein. Protein G is expressed in group C and G streptococcal bacteria. It is a ~60-kDa cell surface protein. It binds to most mammalian immunoglobulins primarily through their Fc regions. The Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor topoisomerase inhibitor, with an IC50 of 0.31 μM. This product is for research use only.

Product Details
Species Reactivity	Bind to most mammalian immunoglobulins primarily through their Fc regions.
Source	E. coli
Type	Recombinant Protein
Measurement	A280 of 0.1% solution: 1.0
Isoelectric point (pI)	4.5
DAR (Drug to Antibody Ratio)	>95% protein conjugated, 1-3 drugs per protein
Conjugate	Protein G conjugated with SMCC-DM1
Purity	>95%
Molecular Weight	~21,600 (Apparent MW by SDS-PAGE: 32,000)
Protein Concentration	1 mg/ml
Formulation	Liquid
Storage Condition	4°C for short time, -20°C or -80°C for long time.
Storage Buffer	20 mM Sodium Borate, 6% Trehalose, pH8.0