Protein G-MMAE (cleavable)

Protein G-MMAE is a Protein-drug conjugate (PDC) of Protein G with microtubule-disrupting agent MMAE conjugate through a cleavable linker. >95% protein G were conjugated with MMAE, the DPR (drug protein ratio) n = 1-3 drugs per protein. Protein G is expressed in group C and G streptococcal bacteria. It is a ~60-kDa cell surface protein. It binds to most mammalian immunoglobulins primarily through their Fc regions. MMAE is a synthetic antineoplastic agent. It is also a microtubule-disrupting agent. This product is for research use only.

Product Details
Species Reactivity	Bind to most mammalian immunoglobulins primarily through their Fc regions.
Source	E. coli
Type	Recombinant Protein
Measurement	A280 of 0.1% solution: 1.0
Isoelectric point (pI)	4.5
DAR (Drug to Antibody Ratio)	>95% protein conjugated, 1-3 drugs per protein
Conjugate	Protein G conjugated with -VC-PAB-MMAE
Purity	>95%
Molecular Weight	~21,600 (Apparent MW by SDS-PAGE: 32,000)
Protein Concentration	1 mg/ml
Formulation	Liquid
Storage Condition	4°C for short time, -20°C or -80°C for long time.
Storage Buffer	20 mM Sodium Borate, 6% Trehalose, pH8.0