ELAHERE (Mirvetuximab Soravtansine-gynx) is an ADC drug developed by Immunogen and approved by the FDA in November 2022. It applies to adult patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who are positive for the folate receptor alpha (FRα) and have previously undergone one to three systemic treatment regimens.
ELAHERE is an innovative ADC that incorporates a cleavable linker known as Sulfo-SPDB (1-(2,5-dioxopyrrolidin-1-yl)-oxo-4-(pyridin-2-yldisulfanyl) butane-2-sulfonic acid), which covalently attaches the payload, DM4, a potent anti-tubulin agent (small molecule), to the mirvetuximab antibody, a chimeric IgG1 monoclonal antibody that targets FRα, as described in Figure 1.
The total molecular weight of ELAHERE's active pharmaceutical ingredient (API) is approximately 150 kDa. On average, each antibody molecule is linked to 3.4 DM4 molecules.
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