Pembrolizumab Biosimilar, Human PD-1 Monoclonal Antibody

Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptor. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype with the containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. Pembrolizumab Biosimilar uses the same protein sequences as the therapeutic antibody pembrolizumab.

Product Details
Species Reactivity	Human
Source	The pembrolizumab biosimilar CHO stable cell line
Host/Isotype	Human IgG4 kappa
Class	Monoclonal
Type	Antibody
Immunogen	The human programmed cell death protein 1 (PD-1 or PD1)
Clone	Pembrolizumab Biosimilar
Conjugate	Unconjugated
Purity	>95%
Molecular Weight	146.341 kDa
Protein Concentration	1 mg/ml
Formulation	Liquid
Storage Condition	4°C for short time, -20°C or -80°C for long time.
Storage Buffer	0.2 uM filtered solution, pH 5.5