SM-102-d4 is intended for use as an internal standard for the quantification of SM-102 by GC- or LC-MS. SM-102 is an ionizable cationic lipid (pKa = 6.68) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and plasmid DNA in vitro and in vivo. Intramuscular immunization of LNPs containing SM-102 and encapsulating mRNA encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein increases serum SARS-CoV-2 spike glycoprotein-specific IgG titers in mice. Formulations containing SM-102 have been used in the development of LNPs for delivery of mRNA-based vaccines.
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