SM-102

SM-102

SM-102 is a synthetic ionizable lipid which is used in combination with other lipids to form lipid nanoparticles (LNP) for drug delivery. These are used for the delivery of mRNA-based COVID-19 vaccines. The pKa is 6.68. Reagent grade, for research purpose.

Molecular structure of the compound BP-25499
    • Unit
    • Price
    • Qty
    • 50 MG
    • $280.00
    • 100 MG
    • $400.00
    • 250 MG
    • $850.00
    • 1 G
    • $1370.00

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Product Citations


  1. https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.5c00614
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  5. Bhattacharya, A., Jan, L., Burlak, O., Li, J., Upadhyay, G., Williams, K., ... & Dey, A. K. (2024). Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine. npj Vaccines, 9(1), 72.
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  23. Ghosh, A. R., Habib, R., Mishra, N., Roark, R. S., Akauliya, M., Albowaidey, A. A., ... & Batista, F. D. (2025). Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization. bioRxiv, 2025-06.
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  26. Hołubowicz, R., Du, S. W., Felgner, J., Smidak, R., Choi, E. H., Palczewska, G., ... & Palczewski, K. (2024). Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations. Nature Biomedical Engineering, 1-22.
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  27. Hussain, M., Binici, B., O’Connor, L., & Perrie, Y. (2024). Production of mRNA lipid nanoparticles using advanced crossflow micromixing. Journal of Pharmacy and Pharmacology, 76(12), 1572-1583.
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  29. Hussain, M., Muglikar, A., Brain, D. E., Plant-Hately, A., Liptrott, N., McLoughlin, D. M., & Perrie, Y. (2025). Redefining LNP composition: phospholipid and sterol-driven modulation of mRNA expression and immune outcomes. RSC Pharmaceutics.
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  30. Jakub GOŁĄB, Dominika Nowis, Joanna Kowalska, Jacek Jemielity, Piotr SKLEPKIEWICZ, Mirosław ŚMIETAŃSKI, Olga SOKOŁOWSKA, Paweł Turowski, Hanna KĘDZIERSKA, Marek Baranowski, Tomasz ŚPIEWLA, Agnieszka Popielec. Modified rna for the treatment of cfdna-associated diseases. (WO2025176838A1)
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    https://www.nature.com/articles/s41541-025-01349-w
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