acid-PEG1-Colchicine is a PEGylated linker-payload, where the carboxylic acid can react with primary amine groups in the presence of activators (e.g., EDC or HATU). Colchicine, a plant-derived microtubule polymerization inhibitor, serves as a highly potent ADC payload that is selectively delivered to tumor cells via antibody targeting, where intracellular release disrupts mitosis and induces apoptosis while minimizing systemic toxicity. The molecule's water solubility is elevated by the PEG1 spacer.
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