Mal-Val-Cit-PAB-Colchicine is an cleavable ADC linker-payload which may be used in the construction of antibody-drug conjugation. The Val-Cit dipeptide can be specifically cleaved by cathepsin B. The maleimide group conjugates with thiol-containing biomolecules. Colchicine, a plant-derived microtubule polymerization inhibitor, serves as a highly potent ADC payload that is selectively delivered to tumor cells via antibody targeting, where intracellular release disrupts mitosis and induces apoptosis while minimizing systemic toxicity.
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