Entrectinib (NMS-E628) is an orally active, brain-penetrant inhibitor of TrkA/B/C, ROS1, and ALK (IC50s = 1, 3, 5, 12, and 7 nM, respectively). It induces apoptosis, cell cycle arrest, and has antitumor activity while also reducing bleomycin-induced lung fibrosis in mice. Reagent grade, for research purpose.
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