Sotorasib (AMG-510) is a first-in-class, orally bioavailable KRAS G12C covalent inhibitor that locks KRAS G12C in an inactive GDP-bound state. It reduces tumor volume in KRAS G12C models and inhibits ERK1/2 phosphorylation (IC50 = 68 nM in MIA PaCa-2 cells). Reagent grade, for research purpose.
Usually ships within 24 hours.