Daunorubicin hydrochloride is a potent topoisomerase II inhibitor and anthracycline antibiotic that disrupts DNA and RNA synthesis, inducing apoptosis and necrosis in cancer cells. It’s widely used in oncology research for conditions like leukemia, non-Hodgkin lymphomas, and sarcomas. In mature AML cells, it triggers a reactive oxygen species–dependent sphingomyelin-ceramide pathway, activating the MEKK1-SEK1-JNK cascade and enhancing AP-1 transcription, while immature AML cells show resistance. Its robust antitumor activity and unique mechanistic profile make daunorubicin a vital tool for cancer research and therapeutic development. Reagent grade, for research purpose.
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