BP Lipid 452 is an ionizable lipid analogue of ALC-0315 featuring an ethanolamine head and two carbamate tails, one branched C15 and the other being a bis cyclopropyl fatty acid tail. This alteration has been designed to investigate the effect on the dynamics of lipid nanoparticles as cyclopropane fatty acids have been reported to affect the fluidity and structure of lipid bilayers.
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