Biotin-PEG3-PC-methyltetrazine serves as a photocleavable, PEG linker comprised of a terminal biotin group that can react with amine molecules in the presence of activators such as EDC or HATU. The methyltetrazine group is TCO-reactive and can be employed to convert azido-bearing peptides or proteins into tetrazine-modified peptides or proteins without catalysts or axillary reagents. This structure allows for efficient photorelease of linked molecules, typically achieving over 90% cleavage in 5-25 minutes using a near-UV lamp.
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