Extracellular death factor (EDF) is a linear pentapeptide that initiates the cell death pathway in specific communicating cells. In bacteria, programmed cell death is regulated through quorum sensing, a cell-to-cell communication system. EDF is sensitive to extreme pH, high temperatures, and other cellular stressors. At a concentration of 2.5 ng/ml, EDF effectively induces cell death, significantly reducing population size in certain E. coli cultures.
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