Azido-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker which contains an azide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB functional group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads, while the azide is free to perform click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
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