Azido-PEG5-Val-Cit-PAB-OH serves as a detachable linker for antibody-drug conjugates (ADCs). Its Val-Cit segment is targeted for cleavage by Cathepsin B enzyme, which is exclusively found in lysosomes within cells, ensuring precise payload release. Additionally, the azido group facilitates reaction with DBCO, BCN, or similar Alkyne groups via click chemistry, while the PEG spacer enhances the solubility of the compound in aqueous environments.
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