tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate

tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate


tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate is a PROTAC linker featuring a thalidomide analogue, a hydrophilic PEG spacer, and a t-butyl ester. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. Meanwhile, the t-butyl ester can be hydrolyzed to reveal a carboxylic acid for further derivitization.

Molecular structure of the compound BP-40562
    • Unit
    • Price
    • Qty
    • 250 MG
    • $120.00
    • 500 MG
    • $210.00
    • 1 G
    • $320.00
    • 5 G
    • $980.00

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