tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate is a PROTAC linker featuring a thalidomide analogue, a hydrophilic PEG spacer, and a t-butyl ester. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. Meanwhile, the t-butyl ester can be hydrolyzed to reveal a carboxylic acid for further derivitization.
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