Thalidomide-O-C8-t-butyl ester

Thalidomide-O-C8-t-butyl ester

Thalidomide-O-C8-Boc is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and a t-butyl ester. Thalidomide is an E3 ligase activator, promoting the ubiquitinylation of a given protein. Meanwhile, the t-butyl ester can be hydrolyzed to reveal a carboxylic acid for further derivatization.

Molecular structure of the compound BP-40555
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