Thalidomide-5-(PEG2-Azide) is a PROTAC linker featuring a thalidomide ligand connected to a PEG spacer and an azide group. Azides are click chemistry handles that are capable of reacting with terminal alkynes or strained cyclooctynes. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.
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