Thalidomide-5-(PEG4-Azide) is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and an azide. Thalidomide is a ligand for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction. Meanwhile, azide is a click chemistry handle which readily reacts with terminal alkynes or strained cyclooctynes.
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