BP Lipid 121 is an amino lipid which has a long (11 carbons) lipid tail on the primary ester located at C7 relative to nitrogen amine. The head contains ethanolamine which can efficiently encapsulate mRNA. The secondary ester is introduced, on the ester located at C8 position relative to amine, to improve protein expression in the liver. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. As an analog of SM-102, BP Lipid 121 can be used to enhance the lipid behavior, ionization properties, mRNA encapsulation efficiency, and other functional properties in lipid formulations. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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