4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoic acid
4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoic acid is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters.

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Catalog:
BP-22307
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Name:
4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoic acid
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Formula:
C25H24O7S2
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MW:
500.6
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CAS:
124243-00-1
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Purity:
98%
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Ships Within:
24 Hours
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Storage Condition:
-20°C
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Shipping:
Ambient Temperature
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Availability:
In Stock
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NMR:
View
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SDS:
View