TCO-PEG6-amine

TCO-PEG6-amine

TCO-PEG4-amine is a bifunctional click chemistry reagent consisting of a TCO and an amine group (NH2). Amine is very reactive with active NHS ester or with carboxylic acid in the presence of of activators suh as EDC. TCO moiety enable fast 3rd generation click chemistry with tetrazine molecule. The inverse-electron demand Diels-Alder cycloaddition of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. Please contact us for GMP-grade inquiries. The half-life of TCO is short as it will naturally isomerize into CCO (cis-cycloctene) and lose the reactivity. TCO compound is not recommended for long term storage.

Molecular structure of the compound BP-24159
    • Unit
    • Price
    • Qty
    • 25 MG
    • $230.00
    • 50 MG
    • $380.00
    • 100 MG
    • $650.00

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Product Citations

  1. Jia, T., Saikam, V., Luo, Y., Sheng, X., Fang, J., Kumar, M., & Iyer, S. S. (2024). Combining Bioorthogonal Chemistry with Fluorescent Silica Nanoparticles for the Ultrasensitive Detection of the HIV-1 p24 Antigen. ACS omega, 9(12), 14604-14612.
    https://doi.org/10.1021/acsomega.3c06136