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Antibody BCN-PEG8-VC-PAB-MMAE Conjugation Kits, 3 vial
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Antibody BCN-PEG8-VC-PAB-MMAE Conjugation Kits, 3 vial
Antibody BCN-PEG8-VC-PAB-MMAE Conjugation Kits, 3 vial
Catalog #: bp-50267
Catalog #
Unit
Price
Qty
BP-50267
3x1mg
$2100.00
Usually ships within 24 hours.
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Overview
This antibody BCN-VC-PAB-MMAE Conjugation Kit is designed to conjugate 1 mg of antibody with the chemotherapeutic drug, MMAE via copper-free click chemistry. The linker structure (shown below) is also composed of a cleavable val-cit dipeptide, which enhances drug molecule release to the cell. The monomethyl auristatin E (MMAE) is a synthetic compound that's used to treat cancer as part of an antibody-drug conjugate (ADC). It is a microtubule-targeting agent (MTA) that binds to tubulin, which stops microtubule formation and arrests tumor cells in the cell cycle. MMAE is too toxic to use as a drug on its own, so it's attached to a monoclonal antibody (mAb) that recognizes a specific marker on cancer cells. The mAb directs MMAE to the cancer cells for specific kill the cancer cells. This product is used for research only.
Product Details
Application
cytotoxicity assay, antitumor study, pharmacokinetic study, biodistribution study
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Datasheets and Documents
Datasheet BP-50267.pdf
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