Antibody azido-PEG8-VC-PAB-SN38 Conjugation Kit, 1 vial

This antibody Azido-PEG8-VC-PAB-SN38 Conjugation Kit is designed to conjugate 1 mg of antibody with the chemotherapeutic drug SN38 via copper-free click chemistry. The linker structure (see Datasheets and Documents) is also composed of a cleavable val-cit dipeptide, which enhances drug molecule release to the cell. SN-38 is the active metabolite of the drug, Irinotecan, and its cytotoxic mechanism of action is through the inhibition of topoisomerase-I while it is bound to DNA cleavage complexes. This product is used for research only

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