BMS-986397 is a potent, selective, and orally active cereblon-based molecular glue degrader of casein kinase 1a (CK1a). BMS-986397 induces apoptosis and cell cycle arrest in acute myeloid leukemia (AML) cells. BMS-986397 is a promising agent for the investigation of AML and high-risk myelodysplastic syndromes (HR-MDS).
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