1-Arachidonoyl-d8-rac-glycerol (1-AG-d8) is intended for use as an internal standard for the quantification of 1-AG by GC- or LC-MS. 1-AG is a weak cannabinoid (CB1) receptor agonist and may have other pharmacologic properties. 1-AG is an isomer of 2-AG. 2-AG is chemically unstable and undergoes rapid isomerization to 1-AG (synonymous with 1(3)-AG) both in vitro and in vivo. 1-AG is a frequent contaminant in synthetic 2-AG preparations, and can markedly reduce their cannabinergic potency.
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