MitoCLox consists of the BDP 581/591 fluorophore carrying a diene-containing moiety (C11) and linked with a triphenylphosphonium (TPP) residue via a long flexible linker with two amide bonds. MitoCLox is similar to MitoPerOx but has a longer linker and contains two (vs. one in MitoPerOx) peptide bonds. The flexible linker of MitoCLox mimics the SS-20 peptide (Phe-D-Arg-Phe-Lys-NH2), making the indicator specific for cardiolipin. The linker also increases the cellular permeability of MitoCLox due to additional positive charges.
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