SOS1 activator 1 is a benzimidazole derivative and SOS1 activator with a Kd of 44 nM. It can significantly activate RAS-GTP and regulate the phosphorylation of ERK. SOS1 activator 1 also can serve as a target ligand for synthesizing PROTACs, such as PROTAC SOS1 degrader-1, to induce SOS1 degradation. SOS1 activator 1 can be used in the study of cancer.
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