(2S)-3-amido-(m-PEG12)-2-maleimido-acid-(Val-Cit-PAB-MMAE) is a novel unique branched Maleimide-VC-PAB-MMAE linker-payload molecule designed to address several common shortcomings of conventional ADC designs, including poor physicochemical properties and linker-driven DAR instability. The maleimide moiety reacts with thiol groups on the antibody, while the PEG12 side chain not only helps reduce aggregation, but also accelerates maleimide ring-opening hydrolysis, thereby enhancing DAR stability. In addition, PEG is well known for improving aqueous solubility.
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