Mal-amido-PEG2-Lys(Boc) is a heterobifunctional crosslinker used in chemical biology, drug delivery, and materials science applications. It features two orthogonal reactive handles: a maleimide group for selective conjugation to free thiols (e.g., cysteine residues), and a Boc-protected lysine amine that can be deprotected later to expose a free amine for a second conjugation step. This orthogonality allows sequential, controlled bioconjugation—react the maleimide first, then unmask the amine when ready for the next coupling. The short PEG2 spacer adds aqueous solubility and defined spacing between the two reactive ends, helping minimize aggregation and steric interference. These properties make the linker well suited for building structurally defined architectures such as antibody-drug conjugates (ADCs) and functionalized nanoparticles.
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