DMT7 is an ionizable cationic lipid (pKa= 6.5) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and anticancer agents in vivo. LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and the STING agonist MSA-2 decrease tumor volume, lung metastatic nodule numbers, and lung levels of CD4+ and CD8+ T cells in a 4T1 breast cancer mouse xenograft model of lung metastasis.
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