A28-C6B2 is an ionizable cationic lipid (pKa = 6.43) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing A28-C6B2 accumulate primarily in the spleen in mice after intravenous administration and target F4/80+ macrophages, Cd11c+ dendritic cells, and to a lesser extent, T cells.
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