Lipid 35 is an ionizable cationic lipid (pKa = 7.6) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.LNPs containing lipid 35 and encapsulating mRNA encoding Pseudomonas exotoxin A decrease the number of lung metastases and increase survival in a B16/F10.9 murine melanoma model.
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