4A3-SC10 is an ionizable cationic lipid (pKa = 6.57) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing 4A3-SC10 and encapsulating an mRNA reporter induce reporter expression in 4T1 breast cancer cells, B16/F10 melanoma cells, and AML12 hepatocytes.
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