Lipid C16-C is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid C16-C and encapsulating mRNA encoding HER2-targeting chimeric antigen receptor (CAR) induce CAR expression in human macrophages ex vivo and induce cytotoxicity in HER2-expressing SKOV3 ovarian cancer cells in vitro.
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