DMA4-H228 is an ionizable cationic lipidoid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing DMA4-H228 and encapsulating mRNA encoding ovalbumin decrease tumor volume and increase intratumoral CD8+ T cells and serum anti-ovalbumin IgG titers in a B16/F10-OVA murine melanoma model.
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