Lipid TD5 is an ionizable cationic lipid (pKa = 7.3) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing lipid TD5 undergo endocytosis in a serotonin (5-HT) receptor subtype 1A-dependent manner in primary mouse astrocytes.
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