5(Z)-Dodecenoic acid is a medium-chain unsaturated fatty acid. It is a precursor in the biosynthesis of the sex pheromone 5(Z)-dodecenal. 5(Z)-Dodecenoic acid levels are increased in culture medium from MCF-7 breast cancer cells compared to KMST-6 fibroblasts. Levels of 5(Z)-dodecenoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.
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